John Fulkerson,Michael Brennan,Kamalakannan Velmurugan,Camille Locht
申请号：
US14394689
公开号：
US09926346B2
申请日:
2012.04.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
