Albany Molecular Research, INC.;The United States of America, as Represented by the Secretary, Department of Health and Human Services
发明人:
申请号:
EP12198010.6
公开号:
EP2573080A1
申请日:
2008.09.26
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Disclosed is a compound of Formula Iin which W and R1-R6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.