Yeshwant Gokhale;Cletus John Nunes;Xiaotian Yin;Gretchen M. Schroeder;Dilbir S. Bindra;Victor W. Rosso;Ajit B. Thakur
发明人:
Dilbir S. Bindra,Yeshwant Gokhale,Cletus John Nunes,Victor W. Rosso,Gretchen M. Schroeder,Ajit B. Thakur,Xiaotian Yin
申请号：
US13643561
公开号：
US20130039989A1
申请日:
2011.04.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are salts and crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof. Also disclosed are at least one pharmaceutical composition comprising at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, at least one method of using at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide to treat cancer and/or other proliferative diseases, and processes to prepare crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof.
