Pharmaceutical compositions comprising N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-l-(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3 -carboxamide

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专利权人:

Bristol-Myers Squibb Company

发明人:

Bindra, Dilbir S.,Gokhale, Madhushree Yeshwant,Nunes, Cletus John,Rosso, Victor W.,Schroeder, Gretchen M.,Thakur, Ajit B.,Yin, Xiaotian

申请号：

AU2011245269

公开号：

AU2011245269B2

申请日:

2011.04.29

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Disclosed are salts and crystalline forms of N-(4-(2-amino-3-chloropyridin-4- yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3- carboxamide and salts thereof. Also disclosed are at least one pharmaceutical composition comprising at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4- yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3- carboxamide, at least one method of using at least one crystalline form of N-(4-(2-amino- 3 -chloropyridin-4-yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2- dihydropyridine-3 -carboxamide to treat cancer and/or other proliferative diseases, and processes to prepare crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3- fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof.

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