PHARMACEUTICAL COMPOSITIONS COMPRISING N-(4-(2-AMINO-3-CHLOROPYRIDIN-4-YLOXY)-3-FLUOROPHENYL)-4-ETHOXY-L-(4-FLUOROPHENYL)-2-OXO- 1,2-DIHYDROPYRIDINE-3 -CARBOXAMIDE

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

BINDRA, DILBIR, S.,GOKHALE, MADHUSHREE YESHWANT,NUNES, CLETUS JOHN,ROSSO, VICTOR W.,SCHROEDER, GRETCHEN, M.,THAKUR, AJIT, B.,YIN, XIAOTIAN

申请号：

SG2012076865

公开号：

SG184891A1

申请日:

2011.04.29

申请国别(地区):

SG

年份:

2012

代理人:

摘要：

Disclosed are salts and crystalline forms of N-(4-(2-amino-3-chloropyridin-4- yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3- carboxamide and salts thereof. Also disclosed are at least one pharmaceutical composition comprising at least one crystalline form of N-(4-(2-amino-3-chloropyridin-4- yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3- carboxamide, at least one method of using at least one crystalline form of N-(4-(2-amino- 3 -chloropyridin-4-yloxy)-3 -fluorophenyl)-4-ethoxy- 1 -(4-fluorophenyl)-2-oxo- 1,2- dihydropyridine-3 -carboxamide to treat cancer and/or other proliferative diseases, and processes to prepare crystalline forms of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3- fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide and salts thereof.

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