The invention discloses antibody drug conjugates, intermediate, preparation method, pharmaceutical composition and application.The present invention design synthesized a series of novel structure, to acid and the stable antibody drug conjugates IB of peptidase cathepsin, the ehter bond that the present invention designs the antibody drug conjugates stability in use of synthesis good is attached, hence it is evident that improve water solublity and stability.The test of internal and external activity all shows that it has a higher cytotoxicity, and wherein the cytotoxicity of moiety thing is better than or close to T DM1.Additionally, the angle chemically synthesized is said, the step of this series conjugate synthesis is simple, and yield is far above T DM1, also allows for further structural modification to improve physicochemical property and the biological activity of conjugate, has good market application foreground.
