Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof

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专利权人:

Gabriella Campadelli;Laura Menotti

发明人:

Gabriella Campadelli,Laura Menotti

申请号：

US12953528

公开号：

US09157071B2

申请日:

2010.11.24

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion； the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC； uses of the modified HSV and a process of the preparation thereof are also disclosed.

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中国工程科技知识中心

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http://www.ckcest.cn/home/