HERPES SIMPLEX VIRUS (HSV) WITH MODIFIED TROPISM, USES AND PROCESS OF PREPARATION THEREOF

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专利权人:

ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

发明人:

GABRIELLA CAMPADELLI,LAURA MENOTTI

申请号：

US14864098

公开号：

US20160074448A1

申请日:

2015.09.24

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion； the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC； uses of the modified HSV and a process of the preparation thereof are also disclosed.

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