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含抗體製劑
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
SAEKI, ATSUSHI,佐伯厚,NISHIZAWA, SHAW,西泽翔,西澤翔,SASAKI, HITOSHI,佐佐木仁,IMAI, CHIFUMI,今井千史,IGAWA, TOMOYUKI,井川智之
申请号:
TW106114061
公开号:
TW201737942A
申请日:
2017.04.27
申请国别(地区):
TW
年份:
2017
代理人:
摘要:
The present invention relates to a stable antibody-containing liquid preparation which rarely undergoes the formation of aggregates of Emicizumab (ACE910) that is a bispecific antibody having a function alternative to the function of FVIII. More specifically, the present invention relates to the aforementioned antibody-containing liquid preparation which contains 20 to 180 mg/mL of the aforementioned bispecific antibody, 10 to 40 mM of a histidine-aspartate buffer solution, 0.2 to 1 mg/mL of Poloxamer 188 and 100 to 300 mM of arginine and has a pH value of 4.5 to 6.5.本發明係有關於取代FVIII功能之雙重專一性抗體Emicizumab(ACE910)之可抑制聚集體形成之含安定之抗體的溶液製劑,具體來說,係關於為含有20~180mg/mL上述雙重專一性抗體、10mM~40mM組胺酸-天門冬胺酸鹽緩衝液、0.2~1mg/mL Poloxamer 188及100mM~300mM精胺酸,pH值為4.5~6.5之上述含抗體溶液製劑。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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