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METHODS FOR MAKING PHARMACEUTICAL SOLID DOSAGE FORMS OF SPRAY-DRIED DISPERSIONS
专利权人:
Yung-Chi LEE
发明人:
Yung-Chi Lee,David Harris,Justin David Moser,Michael McNevin,Amber Broadbent,Robert Hall,Ari Ericson
申请号:
US15749934
公开号:
US20180221282A1
申请日:
2016.07.29
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A process for drying a spray dried dispersion, comprising: a) providing a spray-dried dispersion comprising particles wherein the particles comprise an active agent and a polymer and optionally one or more surfactants, the dispersion having an average particle diameter of less than about 100 m b) blending an amount of silicon dioxide with the dispersion to form a dispersion-silicon dioxide blend, wherein the amount of silicon dioxide relative to the amount of dispersion is between about 0.5 and 2.0% by weight c) drying the blend with a secondary dryer.
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