PHARMACEUTICAL FORMULATIONS OF N-(2-(2-(DIMETHYLAMINO)ETHOXY)-4-METHOXY-5-((4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)ACRYLAMIDE AND SALTS THEREOF
GRECO, Michael,COSTANZO, Michael,GREEN, Michael,PENG, Jirong,WILDE, Victoria,ZHANG, Don
申请号:
SG11201911859Q
公开号:
SG11201911859QA
申请日:
2018.06.15
申请国别(地区):
SG
年份:
2020
代理人:
摘要:
A pharmaceutical formulation of N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide (compound 1), in particular methanesulfonic acid salt thereof, and methods of using the pharmaceutical formulation for the treatment or prevention of diseases or medical conditions mediated through mutated forms of epidermal growth factor receptor (EGFR), such as various cancers, are disclosed.