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CONJUGUES MULTIFONCTIONNELS BORES DE MEDICAMENTS DE CIBLAGE, LEURS UTILISATIONS ET PROCEDES POUR LEUR PREPARATION
专利权人:
HOVIONE SCIENTIA LIMITED
发明人:
GOIS, PEDRO,SANTOS, FABIO
申请号:
CA3054477
公开号:
CA3054477A1
申请日:
2018.03.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
Tri-component multi-functional boronated complexes (B-complexes), featuring reversible covalent bonds, are described, which incorporate a drug;a water-soluble moiety (e.g. polyethylene glycol (PEG) chains, cyclodextrins);and a targeting unit. A B- complex core was assembled in one step, and proved to be stable in different biocompatible conditions, such as human plasma, though reversible for example in the presence of glutathione (GSH). This platform enabled the modular construction of the multifunctional conjugates exhibiting high selectivity towards, for example, folate- receptor-positive MDA-MB-231 cancer cells, having an IC50 in the low nanomolar range.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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