Boronated multifunctional targeting drug conjugates, their uses and methods for their preparation

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专利权人:

Hovione Scientia Limited

发明人:

Gois, Pedro,Santos, Fabio

申请号：

AU2018228369

公开号：

AU2018228369A1

申请日:

2018.03.01

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Tri-component multi-functional boronated complexes (B-complexes), featuring reversible covalent bonds, are described, which incorporate a drug；a water-soluble moiety (e.g. polyethylene glycol (PEG) chains, cyclodextrins)；and a targeting unit. A B- complex core was assembled in one step, and proved to be stable in different biocompatible conditions, such as human plasma, though reversible for example in the presence of glutathione (GSH). This platform enabled the modular construction of the multifunctional conjugates exhibiting high selectivity towards, for example, folate- receptor-positive MDA-MB-231 cancer cells, having an IC

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