Redgrave, Alison Judith,Cooper, Anthony William James,Cook, Caroline Mary,Mitchell, Charlotte Jane,Edlin, Christopher David,Allen, David George,Coe, Diane Mary,Hamblin, Julie Nicole,Johnson, Martin Re
申请号：
AU2010202035
公开号：
AU2010202035B9
申请日:
2010.05.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010202035B920120913.pdf#####Abstract The invention relates to a compound of formula (I) or a salt thereof: Formula (I) wherein: R1 is C .4alkyl, C1.3fluoroalkyl or -(CH 2)20H； R2 is a hydrogen atom (H), methyl or Cifluoroalkyl； R3a is a hydrogen atom (H) or C1.3alkyl； R3 is optionally substituted 5 branched C3 .6 alkyl, optionally substituted C3.scycloalkyl, optionally substituted monounsaturated-C 5.7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), or (bb) or (cc) in which nI and n2 independently are I or 2； and Y is 0, S, SO 2 , or NR4, and wherein Het is of sub-formula (i), or (ii), or (iii), or (iv) or (v). The compounds are phosphodiesterase (PDE) inhibitors, in particular 10 PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis. 15
