ANNA KARIN BELFRAGE,BJÖRN CLASSON,DANIEL JÖNSSON,ELLEN HEWITT,HORST WÄHLING,LOURDES ODEN,MAGNUS NILSSON,MIKAEL PELCMAN,PETER LIND,PIA KAHNBERG,SUSANA AYESA,URSZULA GRABOWSKA,VLADIMIR IVANOV
申请号：
BRPI0922283
公开号：
BRPI0922283A2
申请日:
2009.12.18
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Compounds of the formula I wherein R1a is H； and R1b is C1-C6 alkyl, Carbocyclyl or Het； or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms； R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy； or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl； R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl, R4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof； are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.
