Compounds of the formula IwhereinR1a is H； and R1b is C1-C6 alkyl, Carbocyclyl or Het； orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms；R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy； orR2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl；R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl,R4 is Het, Carbocyclyl,optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof； are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.
