INHIBITEUR DE BROMODOMAINE BET PRÉSENTANT UNE SYNERGIE AVEC PLUSIEURS AGENTS ANTI-CANCÉREUX DANS DES MODÈLES CLINIQUES DE LYMPHOME DIFFUS DE CELLULE B DE GRANDE TAILLE (DLBCL)
INGHIRAMI, Giorgio;BERTONI, Francesco;ONCOETHIX SA
发明人:
BERTONI, Francesco,INGHIRAMI, Giorgio
申请号：
EPEP2014/002165
公开号：
WO2015/018522A1
申请日:
2014.08.06
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A method of treating diffuse large B cell lymphoma in a mammal comprising the step of: administering a pharmaceutical acceptable amount of a combination of anti-cancer drugs to a patient wherein the combination includes a first compound and a second compound； the first compound being selected from the group consisting of an mTOR inhibitor, a BTK inhibitor, an HDAC inhibitor, an anti-CD20 monoclonal antibody, a hypomethylating agent and an immunomodulant, and the second compound being a thienotriazolodiazepine compound being represented by the following Formula (1): wherein R1 is alkyl having a carbon number of 1-4, R2 is a hydrogen atom； a halogen atom； or alkyl having a carbon number of 1 -4 optionally substituted by a halogen atom or a hydroxyl group, R3 is a halogen atom； phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano；— NR5— (CH2)m— R6 wherein R5 is a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and R6 is phenyl or pyridyl optionally substituted by a halogen atom； or -NR7— CO— (CH2)n— R8 wherein R7 is a hydrogen atom or alkyl having a carbon number of 1-4, n is an integer of 0-2, and R8 is phenyl or pyridyl optionally substituted by a halogen atom, and R4 is— (CH2)a— CO— NH— R9 wherein a is an integer of 1-4, and R9 is alkyl having a carbon number of 1 -4； hydroxyalkyl having a carbon number of 1-4； alkoxy having a carbon number of 1 -4； or phenyl or pyridyl optionally substituted by alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1 -4, amino or a hydroxyl group or— (CH2)b— COOR10 wherein b is an integer of 1 -4, and R10 is alkyl having a carbon number of 1-4, or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof.L'invention concerne procédé de traitement de lymphome diffus de cellule B de grande taille chez un mammifère, comprenant l'étape consistant à administrer une quantité pharmaceutiquement accep
