A method for treating atherosclerosis and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject suffering or suspected to suffer atherosclerosis and related diseases thereof. Also provided are a medicine, pharmaceutical composition, product, and kit comprising plasminogen and used for treating atherosclerosis and related diseases thereof of a subject.本發明涉及用於治療受試者動脈粥樣硬化及其相關病症的方法,包括給藥受試者預防和/或治療有效量的纖溶酶原,所述受試者患有或懷疑患有動脈粥樣硬化及其相關病症。本發明還涉及用於治療受試者動脈粥樣硬化及其相關病症的包含纖溶酶原的藥物、藥物組合物、製品、試劑盒。