A method for treating and preventing atherosclerosis, comprising administering a preventively effective amount of plasminogen to a subject prone to suffer atherosclerosis. Also provided are a medicine, pharmaceutical composition, product, and kit comprising plasminogen and used for treating and preventing atherosclerosis.本發明涉及一種預防動脈粥樣硬化的方法,包括給藥易患動脈粥樣硬化的受試者預防有效量的纖溶酶原。本發明還涉及用於預防動脈粥樣硬化的包含纖溶酶原的藥物、藥物組合物、製品、試劑盒。