The present invention relates to the compositions comprising DHA, EPA, LA and GLA. The composition can also include other ω -3PUFAs, MUFAs, SFAs, gama tocopherol, vitamin A and vitamin Es. Composition can treat neurological conditions with what. Composition is by chronic administration, to prevent and/or treat multiple sclerosis (MS) and other degenerative diseases.本發明涉及包含DHA、EPA、LA和GLA的組合物。所述組合物可還包含其他ω-3PUFAs、MUFAs、SFAs、γ生育酚、維生素A和維生素E。組合物可用於治療神經系統病症。組合物被長期施用,以預防和/或治療多發性硬化(MS)和其他退行性疾病。