Jason Allan Wiles,Avinash S. Phadke,Milind Deshpande,Atul Agarwal,Dawei Chen,Venkat Rao Gadhachanda,Akihiro Hashimoto,Godwin Pais,Qiuping Wang,Xiangzhu Wang
申请号：
US15247440
公开号：
US10138225B2
申请日:
2016.08.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein are capable of reducing the excessive activation of complement.
