The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.本發明係關於具有抗增殖活性之新穎苯并二氮呯衍生物，且更具體言之，關於式(I)至(VII)之新穎苯并二氮呯化合物。本發明亦提供苯并二氮呯化合物與細胞結合劑連接之連結物。本發明還提供可用於使用本發明化合物或連結物在哺乳動物中抑制異常細胞生長或治療增生性病症之組合物及方法。
