The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.本發明大體上關於吡咯並苯並二氮呯類衍生物及彼等之抗體-藥物共軛物類且關於使用該等共軛物類作為治療劑和/或診斷劑之方法。