TINO Joseph A.,SRIVASTAVA Anurag S.,KO Soo Sung,GALELLA Michael A.,LANGEVINE Charles M.,DELUCCA George V.,LIU Qingjie,BATT Douglas G.,WATTERSON Scott Hunter,SHI Qing,BERTRAND Myra Beaudoin,DELUCC
申请号：
SI201430268
公开号：
SI3013814T1
申请日:
2014.06.25
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
R1 is F, Cl, —CN, or —CH3； R2 is Cl or —CH3； R3 is —C(CH3)2OH or —CH2CH2OH； Ra is H or —CH3； each Rb is independently F, Cl, —CH3, and/or —OCH3； and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
