XIAO, HAI-YUN,DYCKMAN, ALARIC J.,XIAO, ZILI,YANG, MICHAEL G.,DHAR, T.G. MURALI,GILMORE, JOHN L.,MARCOUX, DAVID
申请号：
CA2958560
公开号：
CA2958560A1
申请日:
2015.08.20
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V) and/or a salt thereof, wherein R1 is OH or OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
