Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors

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专利权人:

发明人:

Siva Sanjeeva Rao Thunuguntla,Subramanya Hosahalli,Satish Reddy Kunnam

申请号：

US15718961

公开号：

US10080740B2

申请日:

2017.09.28

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I)is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R3 which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.

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