Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors

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专利权人:

Aurigene Discovery Technologies Limited

发明人:

Nellore, Kavitha,Hosahalli, Subramanya

申请号：

AU2018260390

公开号：

AU2018260390A1

申请日:

2018.04.19

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R

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