Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors

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专利权人:

Aurigene Discovery Technologies Limited

发明人:

Kavitha Nellore,Subramanya Hosahalli

申请号：

US15899707

公开号：

US20180369206A1

申请日:

2018.02.20

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I)is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R3 which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.

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