Julian Adams,Yun Gao,Asimina T. Georges Evangelinos,Louis Grenier,Roger H. Pak,James R. Porter,James L. Wright
申请号：
US13191761
公开号：
US08252779B2
申请日:
2011.07.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
