LAIRSON, Luke,BOLLONG, Michael,SCHULTZ, Peter G.,CHATTERJEE, Arnab K.,YANG, Baiyuan,KUMAR, Puneet,URKALAN, Kaveri
申请号：
ES14807059
公开号：
ES2755125T3
申请日:
2014.06.05
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of Formula (II), or a pharmaceutically acceptable salt, solvate, polymorph, N-oxide, or stereoisomer thereof: ** Formula ** wherein: A1 is ** Formula ** A2 is ** Formula ** pyridine , pyrazine, pyrimidine, pyridazine or triazine； ** Formula ** B is ** Formula ** C is ** Formula ** D is ** Formula ** E is aryl, heteroaryl, carbocyclyl, heterocyclyl or alkyl； each R1, R2, R3 and R4 is independently selected from H, alkyl, haloalkyl or alkoxy； R7 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylene (NR13R14), cycloalkyl, heterocyclyl, -alkylene (cycloalkyl), or -alkylene (heterocyclyl)； each R8 is independently selected from alkyl, cycloalkyl, heterocyclyl, halo, hydroxy, nitrile, azido, nitro, alkoxy, haloalkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylene (NR13R14), -alkylene (cycloalkyl), -alkylene (heterocyclyl), aryl, heteroaryl, -SR13, -SOR13, -SO2R13, -SO2NR13R14, -NR13R14, -NR13SO2R14, - NR13C (O) R14, -NR13C (O) OR14, -NR13C (O) NR13R14, -C (O) R14, -C (O) OR14 and -C (O) NR13R14； or two adjacent R8s form a heterocyclyl ring； each R13 and R14 is independently selected from H, alkyl, cycloalkyl, heterocyclylalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, arylalkyl, heteroarylalkyl, aryl and heteroaryl； or R13 and R14 taken together form a heterocycle with the atoms to which they are attached； Y1 and Y2 are O； n is 1, 2 or 3； m is 1 or 2； p is 1, 2, 3 or 4； s is 0, 1, 2, 3 or 4； t is 0, 1, 2, 3 or 4； u is 0, 1, 2, 3, 4 or 5； and v is 0； where "alkyl" refers to a linear or branched hydrocarbon chain radical, having from one to thirty carbon atoms, and attached to the rest of the molecule by a single bond； "alkylene" refers to a straight or branched divalent hydrocarbon chain, as described for alkyl； "alkoxy" refers to a radical of the formula -ORa where Ra is an alkyl radical as defined above； "aryl" refers to a radical derived from a hydrocarbon ring system comprising hydrogen, from 6 to 30 carbon atoms and at least one aromatic ring； "cycloalky
