A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I) a known colchicine derivative and/or a salt thereof R wherein: R R R R R R Rand R independently represent hydrogen C alkyl C alkenyl C cycloalkyl halogen C haloalkyl nitro amino C acylamino C alkyl or dialkylamino hydroxyl Calkoxy C alkylthio a group of the formula SON(R) or SOR where R is C alkyl C acyloxy or optionally substituted phenyl optionally substituted phenoxy R and R independently represent hydrogen C alkyl or C acyl and R R " R and R" independently represent hydrogen C alkyl C alkenyl C cycloalkyl halogen C haloalkyl nitro amino C acylamino hydroxyl Calkoxy or C alkylthio a group of the formula SON(R) or SOR where R is C alkyl C acyloxy or optionally substituted phenyl.
