Subash Sad,Lakshmi Krishnan,Fanny Tzelepis,Valeria Alcon,Kevin G. Young
申请号：
US14516090
公开号：
US09539313B2
申请日:
2014.10.16
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumor antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
