Kevin G. Young;Lakshmi Krishnan;Fanny Tzelepis;Valeria Alcon;Subash Sad
发明人:
Subash Sad,Lakshmi Krishnan,Valeria Alcon,Kevin G. Young,Fanny Tzelepis
申请号：
US13811690
公开号：
US20130156809A1
申请日:
2011.07.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
