SAD SUBASH,KRISHNAN LAKSHMI,TZELEPIS FANNY,ALCON VALERIA,YOUNG KEVIN G.
申请号：
IN1528CHN2013
公开号：
IN1528CHN2013A
申请日:
2013.02.25
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism and uses thereof. To this end the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen a bacterial antigen or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
