Paul D. Drumheller,Robert L. Cleek,Todd J. Johnson,Theresa A. Holland
申请号：
US14852708
公开号：
US20160015868A1
申请日:
2015.09.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form wherein the therapeutic agent is paclitaxel and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.
