It describes the nafielding compounds and their use as HPK1 inhibitors. These compounds help to treat HPK1-dependent disorders and enhance immune response. The methods of inhibiting HPK1, treating HPK1 dependence disorder, enhancing immune response and producing Nafidine compounds were also introduced. Claim 1: A formula compound (1),O. Resistant salts containing C832283318329839 heterogeneous components；3. Isopropylene C832283318329；Arilo C832628331-8321； 8320；- C degree C - heterosexual C8322283331；- C (O) N (R690') (heterosexual C832283331；- C (O) N (R690') (isopropylene C832283331)；- CH (R690') - O - (heterosexual C8322833318329)；Cyoquilo C83238C83318329；A. C832183318326 or hydrogen； each R690'is a separate hydrogen or C8331832626；A. Among the independent R1, the abnormal C8322318329 and C8322833183299A have 1-4 abnormal atoms selected from O, S and N, among which tar C832183318326；Cyoquilo C83238C83318329；Arilo C832628331-8321； 8320；E. The isomers C8322833129 and C832283318329R1 can be independently replaced by 1, 2, 3, 4 or 5 alternatives； Arilo C832626-83318321； 8320；E. Isopropylene-C832283318329o or isopropylene-C832283318329831, together with two alternatives, can form an alternative double-cycle alternative； in this case, isopropylene, isopropylene or isopropylene carbon intake with the attached oxygen can form a carbon； 1. Carbide； R1'is hydrogen, tar C83218331832626；Alquenilo C83228331-832626；Cyoquilo C833238832626；E. Non-orthogonal C832283318329o halides, in which such alkyl, acyl, cyclopentyl and heterogenous groups can be selectively replaced by hydroxyl, halogen o r amino groups, provided that at least one R1 and R1'is non-hydrogen, R2 is A-C(o) - or D, A is C83218383226；Alquenilo C83228331-832626；1.C 83228331 asphalt；Cyoquilo C83238C83318327；Arilo C832628331-8321； 8320；A. Heterosexual C832283318329；3. Isopropylene C832283318329；(cycloquilo C8323-833183277a) - C8321833183326a；(Arilo C83266331833121； 83207a) - (Acquileno C8321883266a) -,(Heterogeneous
