BETEBENNER DEHVID A.,PRATT DZHON K.,DEGOJ DEHVID A.,DONNER PAMELA L.,FLENTGE CHARL'Z A.,KHATCHINSON DUGLAS K.,KATI UORREN M.,KRJUGER ALLAN K.,LONGENEKER KENTON L.,MARING KLARENS DZH.,RANDOLF DZHON T.,БЕТЕБЕННЕР Дэвид А.,ПРАТТ Джон К.,ДЕГОЙ Дэвид А.,ДОННЕР Памела Л.,FLENTGE CHARLZ A.,ФЛЕНТГЕ Чарльз А.,ХАТЧИНС
申请号：
RU2011142978
公开号：
RU2571662C2
申请日:
2010.03.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to new compounds of formula (I) and their pharmaceutically acceptable salts, which inter alia inhibit hepatotropic hepatitis C virus and are applicable in treating hepatitis C virus. In formula (I)Ris specified in a group consisting ofis specified in a group consisting of a carbon-carbon single bond and carbon-carbon double bond； R, R, R, R, Rand Rare independently specified in a group consisting of a hydrogen atom, methyl and a protective group for nitrogen specified in Calkylsulphonyl； Rrepresents a hydrogen atom； Ris specified in a group consisting of a halogen atom, Calkyl and heterocyclyl specified in 5-merous heteroaryl with 1-2 heteroatoms specified in nitrogen, oxygen and sulphur, wherein alkyl is optionally substituted by one or more substitute optionally specified in a group consisting of a halogen atom； and heterocyclyl is optionally substituted by Calkyl； Ris specified in a group consisting of Calkyl, Calkenyl, Calkyloxy and a halogen atom； L means a bond, and Ris specified in a group consisting of C-C-carbocyclyl, or Rmeans carbocyclyl with 2 condensed cycles specified in a group consisting of naphthalinyl, indenyl and dihydroindenyl, hexahydroindenyl, octahydroindenyl, wherein each can be substituted by a substitute specified in a group consisting of R, Rand R, and Rmeans hydroxy, oxo； Rmeans Calkyl substituted by Calkylsulphonylamino, imino, wherein imino is substituted by a Calkylsulphonylamino group； and Rmeans an alkylsulphonylamino group； or L is specified in a group consisting of C(R) = C(R), wherein Rand Rmean a hydrogen atom, and Ris specified in a group consisting of Ccarbocyclyl specified in phenyl substituted by Rhaving the above value.EFFECT: higher efficacy of the compound.16 cl, 2 tbl, 52 exИзобретение относится к новым соединениям формулы (I) и их фармацевтически приемлемым солям, которые,, ингибируют гепатотропный вирус HCV и могут быть использованы при лечении вируса гепатита С. В формуле (I)
