Jiandong Yuan,Yangqing Huang,Lingfeng Miao,Jianing Gu,Chaohua Liang,Zhengye Wang,Zhanli Sun
申请号：
US15754009
公开号：
US20180244710A1
申请日:
2016.09.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided is a preparation method of a composition enriched in compound Sp-1. The method performs isomer separation on a reaction product from the first step, and then performs a two-step chemical synthesis, so as to prepare a composition comprising high-purity compound Sp-1, wherein the HPLC purity of the single isomer Sp-1 is 90% or more. Provided is a composition enriched in compound Sp-1. The composition has an inhibitory effect on tumor cell proliferation in vitro significantly higher than that of NUC-1031 and compound Rp-1. Also provided are the use of the composition, and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient.
