AN IMPROVED PROCESS FOR THE PREPARATION OF BENDAMUSTINE HYDROCHLORIDE

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专利权人:

发明人:

MISHRA BHUWAN BHASKAR,KACHHADIA NIKUNJ SHAMBHUBHAI,TOMAR VINOD SINGH,LAHIRI SASWATA

申请号：

IN2795/DEL/2011

公开号：

IN2011DE02795A

申请日:

2011.09.26

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The present invention relates to an improved process for the synthesis of bendamustine, in particular , bendamustine hydrochloride of the formula (VI) and its intermediate l-Methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazol-2-yl]lithium butanoate of formula(V), both having a purity of >99%, which is simple, convenient, economical, does not use hazardous chemicals and industrially viable.

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