Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation

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专利权人:

Philippe Louvet

发明人:

Philippe Louvet,Dominique Schweizer

申请号：

US12984279

公开号：

US08183294B2

申请日:

2011.01.04

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent and optionallyb) isolating the obtained sulphoxide of formula (I).wherein Ar, Y, R1 are as defined in claim 1.

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