#$%^&*AU2016222453A120160922.pdf#####ABSTRACT This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individuals immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the hosts immune system.WO 2011/123396 PCT/US2011/030212 14/20 Robust biofilm with 9 water channels biooilm mucosa adjuvant alone IHF + adjuvant FIG. 10 I 1 b---5------ -----I1e3 HF + adjuvant adjuvant I .10
