UNIVERSITY OF SOUTHERN CALIFORNIA;THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL;THE RESEARCH INSTITUTE AT NATIONWIDE CHILDRENS HOSPITAL
发明人:
GOODMAN, STEVEN D.,BAKALETZ, LAUREN O.
申请号：
SG2012063178
公开号：
SG183816A1
申请日:
2011.03.28
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individuals immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the hosts immune system.
