Research Institute at Nationwide Children's Hospital
发明人:
Steven D. Goodman,Lauren O. Bakaletz
申请号：
US15078987
公开号：
US20160194384A1
申请日:
2016.03.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
