The United States Government as represented by the Department of Veteran Affairs;President and Fellows of Harvard College
发明人:
Thatte, Hemant,Shi, Jialan
申请号：
AU2016274764
公开号：
AU2016274764A1
申请日:
2016.06.09
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Provided herein, inter alia, are compositions and methods for preserving platelets in a lesion-free and functional state during extended storage periods of up to 15 days as well as methods and kits for utilizing the same. In contrast to currently available compositions and techniques for preserving platelets, platelets stored in the compositions disclosed herein are characterized by a marked decrease in "storage-lesions," which are associated with attenuated hemostatic function. During platelet storage, the compositions disclosed herein (1) maintain and/or restore platelet energy states and morphology； (2) maintain active metabolism and buffering； (3) preserve and/or promote nitric oxide production； and (4) prevent microparticle formation, aggregation and activation during storage. As such, long term preservation in the compositions described herein produce platelets that are fully functional and lesion-free.
