CaSR activation (operation) the curative medicine of the hyperparathyroidism, the kidney Characteristic bone strange nutrition symptom and the high calcium blood symptom etc which possess operation is offered.The below-mentioned general formula (1) < Conversion 1 >[In formula, general expression (1) as for Ar of part structure in phenyl group or naphthyl basis R and as for R, equality or differing, the hydrogen atom and the halogeno basis etc R and as for R, equality or differing, the hydrogen atom and the halogeno basis etc As for A, single bond and oxygen atom etc As for B, as for Z such as single bond and C1 - C4 arukanjiiru basis, karubokishi basis or tetrazolyl group m shows integer 1 - 3. ] With the chemical compound which is displayed or the salt which on the pharmacology is allowed.CaSR活性化(作動)作用を有する副甲状腺機能亢進症、腎性骨異栄養症、高カルシウム血症等の治療薬を提供する。下記の一般式(1)【化1】[式中、一般式(1)中の部分構造のArはフェニル基又はナフチル基;R1a及びR1bは、同一又は異なって、水素原子、ハロゲノ基等;R2a及びR2bは、同一又は異なって、水素原子、ハロゲノ基等;Aは、単結合、酸素原子等;Bは、単結合、C1~C4アルカンジイル基等、Zは、カルボキシ基又はテトラゾリル基;mは、1~3の整数を示す。]で表わされる化合物又はその薬理上許容される塩。
