EXPRESSION AND FUNCTION OF GPR64/ADGRG2 IN ENDOCRINE SYSTEMS AND METHODS TO TARGET IT THERAPEUTICALLY

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专利权人:

Nariman Balenga

发明人:

Nariman Balenga,John Olson

申请号：

US15589526

公开号：

US20170333522A1

申请日:

2017.05.08

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Provided herein are methods of treating hypercalcemia in a subject, comprising administering to the subject a therapeutically effective amount of a composition that decreases the expression level and/or activity of GPR64. Compositions comprising the therapeutic agents and methods of screening for agonists and inhibitors of GPR64 are also provided. Compositions and methods for treating primary hyperparathyroidism, secondary hyperparathyroidism, hypoparathyroidism, and osteoporosis without hyperparathyroidism are also provided.

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中国工程科技知识中心

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