Bottley, Andrew,Hayes, Christopher,Seymour, Graham,Grabowska, Anna,Clarke, Philip
申请号：
AU2020202332
公开号：
AU2020202332A1
申请日:
2020.04.02
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020202332A120200423.pdf#####ABSTRACT THERAPY AND PHARMACEUTICAL COMPOSITION A compound of Formula I: 5 Rl-L1-C(A)(A') - CH2 - L2-R2 (I) or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a disease or condition selected from the group 10 comprising cancer, autistic spectrum disorders, Alzheimer's disease, Parkinson's disease, Huntingdon's disease, muscle wasting and viral infection, wherein: R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a Cl-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and 15 a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group； Ll is a linking group； L2 is a linking group； R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 20 derivative of an alkynyl group； A is selected from hydrogen and a C1-C6 alkyl group； A' is selected from hydrogen, a Cl-C6 alkyl group, and L3-R3； wherein L3 is a linking group； and 25 R3 is selected from hydrogen, a Cl-C24 alkyl or a Cl-C24 derivative of an alkyl group, a C2C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group； and wherein if A' is not L3-R3, then R2 is a CO-C24 alkyl or a CO-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or 30 a C10-C24 derivative of an alkynyl group； and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C1OC24 alkynyl group or a C10-C24 derivative of an alkynyl group.
