Ruah, Sara S. Hadida,Grootenhuis, Peter D.J.,Van Goor, Fredrick,Zhou, Jinglan,Bear, Brian,Miller, Mark T.,McCartney, Jason,Numa, Mehdi Michel Jamel,Yang, Xiaoqing
申请号：
ES13167785
公开号：
ES2580803T3
申请日:
2007.04.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula Ic: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1 is -ZAR4, wherein each ZA is independently a branched or linear C1-6 aliphatic chain or chain optionally substituted on the that up to two ZA carbon units are optionally and independently substituted with -CO-, -CS-, -CONRA-, -CONRANRA-, -CO2- -OCO-, -NRACO2-, -O-, -NRACONRA-, - OCONRA-, - NRANRA-, -NRACO-, -S-, -SO-, -SO2- -NRA-, -SO2NRA-, -NRASO2- or -NRASO2NRA-, Each R4 is independently RA, halogen, -OH, - NH2, -NO2, -CN or -OCF3, Each RA is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl or an optionally substituted heteroaryl； Each R2 is independently -ZBR5, in which each ZB is independently an optionally substituted branched or linear C1-6 aliphatic chain or link in which up to two ZB carbon units are optionally and independently substituted with -CO-, -CS -, -CONRB-, -CONRBNRB-, -CO2-, -OCO-, -NRBCO2-, - O-, -NRBCONRB-, -OCONRB-, -NRBNRB-, -NRBCO-, -S-, -SO-, -SO2-, -NRB-, -SO2NRB-, -NRBSO2- or - NRBSO2NRB-, Each R5 is independently RB30, halogen, -OH, -NH2, -NO2, -CN, -CF3 or -OCF3, Each RB is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl； or, any two adjacent R2 groups together with the atoms to which they are attached form an optionally substituted carbocycle or an optionally substituted heterocycle； Ring A is a 3-7 membered monocyclic ring that has 0-3 heteroatoms selected from N, O and S； Ring B is a group having the formula Ia: ** Formula ** or a pharmaceutically acceptable salt thereof, in which p is 0-2, Each R3 and R'3 is independently -ZCR6, in which each ZC it is independently an optionally substituted branched or linear C1-6 aliphatic link or cha
