Hadida Ruah, Sara,Miller, Mark,Zhou, Jinglan,Bear, Brian,Grootenhuis, Peter D. J.
申请号：
ES12181370
公开号：
ES2556080T3
申请日:
2008.11.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, in which independently for each case: R1 is an optionally substituted C1-6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, a optionally substituted 3 to 10-membered heterocycloaliphatic, with the proviso that at least one R1 is an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl attached to position 1 of the isoquinoline ring； R2 is hydrogen, an optionally substituted C1-6 aliphatic； R3 and R'3 together with the carbon atom to which they are attached form an optionally substituted C3-7 cycloaliphatic； R4 is an optionally substituted phenyl； and n is 1. wherein the optional substituents for aryl are aliphatic [eg, alkyl, alkenyl, or alkynyl]； cycloaliphatic； (aliphatic (cycloaliphatic)； heterocycloaliphatic； (heterocycloaliphatic) aliphatic； aryl； heteroaryl； alkoxy； (cycloaliphatic) oxy； (heterocycloaliphatic) oxy； aryloxy； heteroaryloxy； (araliphatic) oxy； (heteroaraliphatic) oxy； aroyl； heteroaroyl； Not me； oxo (in a non-aromatic carbocyclic ring of a benzofused bicyclic or tricyclic aryl)； nitro； carboxy； amido； acyl [eg, aliphaticcarbonyl； (cycloaliphatic) carbonyl； ((cycloaliphatic) aliphatic) carbonyl； (araliphatic) carbonyl； (heterocycloaliphatic) carbonyl； ((heterocycloaliphatic) aliphatic) carbonyl； or (heteroaraliphatic) carbonyl]； sulfonyl [eg, aliphatic sulfonyl or aminosulfonyl]； sulfinyl [eg, aliphaticulfinyl or cycloaliphaticulfinyl]； sulfanyl [eg, aliphatic sulfanyl]； cyano； halo； hydroxy； mercapto； sulfoxy； urea； thiourea； sulfamoyl； sulfonamide； or carbamoyl, wherein the optional substituents for heteroaryl are aliphatic [eg, alkyl, alkenyl, or alkynyl]； cycloaliphatic； (aliphatic (cycloaliphatic)； heterocycloaliphatic； (heterocycloaliphatic) aliphatic； aryl； heteroaryl； alkoxy； (cycloaliphatic) oxy； (heterocycloaliphatic) oxy； aryloxy； heteroaryloxy； (araliphati
