HADIDA RUAH, Sara,MILLER, Mark,ZHOU, Jinglan,BEAR, Brian,GROOTENHUIS, Peter
申请号：
ES15180766
公开号：
ES2658064T3
申请日:
2008.11.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, in which independently for each case: R1 is an optionally substituted heterocycloaliphatic, an optionally substituted aryl or an optionally substituted heteroaryl attached to position 1 of the isoquinoline ring； R2 is hydrogen, p an optionally substituted C1-6 aliphatic； R3 and R'3 together with the carbon atom to which they are attached form an optionally substituted C3-7 cycloaliphatic； R4 is an optionally substituted phenyl； and n is 1. in which the optional substituents for aryl are aliphatic [eg, alkyl, alkenyl, or alkynyl]； cycloaliphatic； (aliphatic (cycloaliphatic)； heterocycloaliphatic； (heterocycloaliphatic) aliphatic； aryl； heteroaryl； alkoxy； (cycloaliphatic) oxy； (heterocycloaliphatic) oxy； aryloxy； heteroaryloxy； (araliphatic) oxy； (heteroaraliphatic) oxy； aroyl； heteroaroyl； Not me； oxo (in a non-aromatic carbocyclic ring of a benzofused bicyclic or tricyclic aryl)； nitro； carboxy； amido； acyl [eg, aliphaticcarbonyl； (cycloaliphatic) carbonyl； ((cycloaliphatic) aliphatic) carbonyl； (araliphatic) carbonyl； (heterocycloaliphatic) carbonyl； ((heterocycloaliphatic) aliphatic) carbonyl； or (heteroaraliphatic) carbonyl]； sulfonyl [eg, aliphatic sulfonyl or aminosulfonyl]； sulfinyl [eg, aliphaticulfinyl or cycloaliphaticulfinyl]； sulfanyl [eg, aliphatic sulfanyl]； cyano； halo； hydroxy； mercapto； sulfoxy； urea； thiourea； sulfamoyl； sulfonamide； or carbamoyl, wherein the optional substituents for heteroaryl are aliphatic [eg, alkyl, alkenyl, or alkynyl]； cycloaliphatic； (aliphatic (cycloaliphatic)； heterocycloaliphatic； (heterocycloaliphatic) aliphatic； aryl； heteroaryl； alkoxy； (cycloaliphatic) oxy； (heterocycloaliphatic) oxy； aryloxy； heteroaryloxy； (araliphatic) oxy； (heteroaraliphatic) oxy； aroyl； heteroaroyl； Not me； oxo (in a non-aromatic carbocyclic or heterocyclic ring of a bicyclic or tricyclic heteroaryl)； carboxy； amido； acyl [eg, aliphaticcarbonyl； (cycloaliphat
